Assistant Professor, Department Neurosurgery 1365B Clifton Rd., NE, Ste. 6200 Atlanta, GA 30322 Appt. Phone: 404-778-5770

Dr. Boulis currently has a unique opportunity available for a Postdoctoral Fellow at Emory University. Qualified candidates with prior neuroscience research experience who are interested in the position can learn more about application on the Emory Careers website or call 404.727.2247.
(Job Requisition ID: 2562BR)

• Areas of Clinical Interest
• Publications
• Manuscripts in Preparation
• Book Chapters
• Abstracts
• Research

Dr. Nicholas Boulis is a physician scientist whose research interests include biological neurorestoration and neuromodulation through the use of cell, protein, and gene delivery to the nervous system. Dr. Boulis graduated summa cum laude from Yale University with distinction in the intensive Biology and Philosophy majors. He graduated magna cum laude from Harvard Medical School, winning the Harold Lamport Biomedical Research Award. Dr. Boulis developed a clinical program focusing on peripheral nerve regeneration, spasticity, pain and Parkinson's Disease, applying advanced microsurgical, radiosurgical and ablative and neural augmentation approaches. Dr. Boulis is author of over 46 publications. He has independently organized and secured funding for an outreach/teaching mission to provide surgical therapy to patients in Guatemala requiring treatment for hydrocephalus and spina bifida. To date, "Project Shunt" has provided over 250 free operations to impoverished Guatemalan children.


Areas of Clinical Interest:

• Functional Neurosurgery
• Trigeminal Neuralgia
• Refractory Pain
• Peripheral Nerve Surgery

Publications

Boulis NM, and Sahley C (1988) A behavioral analysis of habituation and sensitization of shortening in the semi-intact leech. J. Neuroscience 8: 4621-4627

Davis M, Commissaris R, Yang C, Wagner A, Kehne J, Cassella J, and Boulis NM (1989) Spinal vs. supraspinal sites of action of the a2-adrenergic agonists clonidine and ST-91 on the acoustic startle reflex. Pharmacology, Biochemistry, and Behavior 33: 233-240

Altemus M, Wexler B, and Boulis NM (1989) Neuropsychological correlates of menstrual mood changes. J of Psychosomatic Med. 51: 329-336

Altemus M, Wexler B, and Boulis NM (1989) Changes in perceptual asymmetry with the menstrual cycle. Neuropsychologia 27: 233-240

Boulis NM, and Davis M (1989) Foot-shock induced sensitization of electrically elicited startle reflexes. Behavioral Neuroscience 103: 504-508

Boulis NM, Miserendino M, Kehne J, and Davis M (1990) Differential blockade of early and late components of acoustic startle following intrathecal infusion of CNQX or AP-5. Brain Research 520: 240-246

Boulis NM, and Davis M (1990) Blockade of the spinal excitatory effects of cAMP on the startle reflex by intrathecal administration of the isoquinolinesulfonamides H-8: Comparison to the protein kinase C inhibitor H-7. Brain Research 525: 198-203

Kehne J, Boulis NM, and Davis M (1991) The effects of the phosphodiesterase inhibitor rolipram on the acoustic startle response. Psychopharmacology 105: 27-36

Ehrlich J, Boulis NM, Karrer T, and Sahley C (1992) Differential effects of serotonin depletion on sensitization and dishabituation in the leech Hirudo medicinalis. J . Neurobiology 23(3):270-279

Boulis NM, Sathi S, Schwartz R, DeGirolami U and Black P McL. (1994) Neuro-glial hamartoma of the suprasellar cistern. Surgical Neurology 41:494-7

Schwalb JM, Boulis NM, Gu M-F, Winicoff J, Irwin N, Jackson PS, Benowitz LI. (1995) Two factors secreted by cells of the goldfish optic nerve induce retinal ganglion cells to regenerate axons in culture. J Neuroscience 15(8): 5514-5525

Sahley CL, Boulis NM, Schurman B. (1994) Associative learning modifies the shortening reflex in the semi-intact leech Hirudo medicinalis: Effects of Pairing, predictability, and CS preexposure. Behavioral Neuroscience 108(2):340-346

Sahley CL, Modney BK, Boulis NM, Muller KJ. (1994) The S cell: An interneuron essential for sensitization and full dishabituation of leech shortening. J Neuroscience, 14(11):6715-6721

Schwalb JM, Gu M-F, Stuermer C, Bastmeyer M, Hu G-F, Boulis N, Irwin N, and Benowitz LI. (1996) Optic nerve glia secrete a low molecular weight factor that stimulates retinal ganglion cells to regenerate axons in goldfish. Neuroscience 72(4):901-910

Boulis NM, Bhatia V, Brindle TI, Holman HT, Krauss DJ, Blaivus M, Hoff JT. (1999) Adenoviral nerve growth factor and b-galactosidase transfer to spinal cord: A behavioral and histological analysis. J Neurosurgery (Spine 1) 90:99-108

Boulis NM. (1998) On Rabbit's Feet and Reason. Lancet 352: 1640

Boulis NM, Armstrong WA, Chandler W, Orringer M. (1999) Epidural abscess following esophageal stenting for benign disease. Annals of Thoracic Surgery 68:568-70

Boulis NM, Turner DE, Dice JA, Bhatia V, Feldman EL. (1999) Characterization of adenoviral gene expression in spinal cord following remote vector delivery. Neurosurgery 45: 131-138

Boulis NM, Bobek MP, Schmaier A, Hoff JT. (1999) Use of factor IX complex in warfarin-related intracranial hemorrhage. Neurosurgery 45(5): 1113-1118

Boulis NM. Sisyphus and the outpatients. (2000) Lancet 356: 350 21. Gong C, Boulis NM, Jun G, Turner DE, Hoff JT, Keep RF. (2001) Intracerebral Hemorrhage-induced neuronal death. Neurosurgery 48(4):875-82

Boulis NM, Mian F, Rodriguez DJ, Cho EJ, Hoff JT. (2001) Urinary retention in postoperative neurosurgical routine spine procedures. Surgical Neurology 55(1):23-7

Boulis NM, Noordmans AJ, Barkan A, Hassing J, Chandler WF (2000). Somatotropinoma infarction during Octreotide therapy leading to bilateral cavernous sinus syndrome. Pituitary 3:185-188

Turner DE, Noordmans AJ, Feldman EL, Boulis NM (2001). Remote adenoviral gene delivery to the spinal cord: contralateral delivery and reinjection. Neurosurgery 48(6):1309-1317

Boulis NM, Turner DE, Imperiale MJ, Feldman EL. (2002) Neuronal survival following remote adenoviral gene delivery. J Neurosurg:( Spine 2) 96: 212-219.

Song D, Boulis NM, McKeever, Quint D. (2002) Angiotropic large cell lymphoma presenting with imaging characteristics of CNS vasculitis. American Journal of Neuroradiology 23(2):239-42.

Rubin AD, Hogikyan ND, Sullivan K, Boulis N, Feldman EL. (2001) Remote delivery of rAAV-GFP to the rat brainstem through the recurrent laryngeal nerve. The Laryngoscope 111(11 Pt 1):2041-5.

Boulis NM. (2001) There was a young surgeon who swallowed a flea. Canadian Medical Association Journal165(12): 1613-1614.

Boulis NM, Willmarth NE, Song DK, Feldman EL, Imperiale MJ. (2003) Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery. Neurosurgery 52(2)381-387.

Rubin A, Hogikyan N, Bell K, Sullivan K, Boulis NM, Feldman EL. (2003) Remote delivery of an adenoviral vector to the crushed recurrent laryngeal nerve. Laryngoscope113: 985-989.

Noordmans AJ, Parent N, Bhatia V, Garrity-Moses M, Boulis NM. (2003) Rigid postoperative fixation for pedicled cranial flaps: A case comparison. J of Orthotics and Prosthetics15(1):27-30.

Boulis NM, Noordmans AJ, Song DK, Rubin A, Leone P, During M, Feldman EL, Imperiale MJ. (2003) Adeno-associated Viral Vector Gene Expression in the Adult Rat Spinal Cord Following Remote Vector Delivery. Neurobiology of Disease 14(3): 531-541.

Noordmans AJ, Song DK, Noordmans CJ, During MJ, Fitzsimons H, Imperiale MJ, Boulis NM. (2004) Adeno-associated viral glutamate decarboxylase expression in the lateral nucleus of the rat hypothalamus reduces feeding behavior. Gene Therapy 11: 797-804.

Tanase D, Teng Q, Krishnaney AA, Liu JK, Garrity-Moses ME, Mazarakis N, Boulis NM. (2004) Cervical spinal cord delivery of a rabies G protein pseudotyped lentiviral vector in the SOD-1 transgenic mouse. J Neurosug (Spine 1) 1: 128-136.

Teng Q, Tanase D, Liu J, Garrity-Moses M, Boulis NM. (2005) Adenoviral Tetanus Toxin Light Chain Gene-Based Synaptic Inhibition through Neuronal Synaptobrevin Elimination. Gene Therapy 12(2) 108-119.

Vincent A, Feldman E, Song D, Jung V, Schild A, Zhang W, Imperiale M, Boulis NM. (2004) Adeno-associated Viral-mediated Insulin-like Growth Factor Delivery Protects Motor Neurons In Vitro. NeuroMolecular Medicine 6(2/3): 79-85.

Schuele SU, Kellinghaus C, Shook S, Boulis NM, Bethoux FA, Loddenkemper T. (2005) Incidence of seizures in multiple sclerosis patients on intrathecal baclofen. Neurology, 64: 1086-1087.

Liu J,Teng Q, Garrity-Moses M, Tanase D, Imperiale M, Boulis NM. (2005) A Novel Peptide Defined Through Phage Display for Therapeutic Protein and Vector Neuronal Targeting. Neurobiology of Disease 19(3): 407-418.

Garrity-Moses M, Teng Q, Liu J, Tanase D, Boulis NM. (2005) Neuroprotective adeno-associated virus Bcl-xL gene transfer in models of motor neuron disease. Muscle and Nerve 32(6): 734-744.

Teng, Q, Garrity-Moses M, Tanase D, Liu JK, Mazarakis N, Azzouz M, Walmsley L, Carlton E, Boulis NM. (2005) Trophic activity of rabies G protein pseudotyped equine infectious anemia viral vector mediated IGF-I motor neuron gene transfer in vitro. Neurobiology of Disease 20(3): 694-700.

Pilitsis JG, Rezai AR, Boulis NM, Hendersen JM, Busch RM, Kubu CS. (2005) A preliminary study of transient confusional states following bilateral subthalamic stimulation for Parkinson's disease. Stereotactic and Functional Neurosurgery 83(2-3): 67-70.

Salazar F, Machado A, Stevens G, Murthy S, Boulis NM. (2005) Thoracoscopically Guided Transaxillary Resection of Adjoining Intercostal Plexiform Neurofibromas; Review of Mosaicism in Neurofibromatosis. Neurosurgery 57(4)(Operative Neurosurgery Supp 4): E407.

Federici, T and Boulis, NM. (2006) Gene-based treatment of motor neuron disease. Muscle and Nerve 33(3): 302-323.

Zhao Z, Krishnaney A, Teng Q, Garrity-Moses M, Liu JK, Venkiteswaran K, Subramanian T, Davis M, Boulis NM. (2006) Anatomically discrete functional effects of adenoviral clostridial light chain gene-based synaptic inhibition in the deep layers of the superior colliculus/deep mesencephalic nucleus of the midbrain. Gene Therapy, 13; 942-952.

Garrity-Moses M, Teng Q, Krudy C, Yang J, Federici T, Boulis NM. (2006) XIAP Gene-based Neuroprotection for the Peripheral Nervous System. Neurosurgery 59(1): 172-182.

Federici T, Teng Q, Yang J, Garrity-Moses M, Boulis NM. (2006) Neuronal affinity of a C7C loop peptide identified through phage display. Journal of Drug Targeting, 14(5):263-71.

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Accepted for Publication in Peer-Reviewed Journals

Federici T and Boulis NM. RNA interference for neurological disorders: candidate diseases, potential targets, and current approaches. Neurosurgery in press.

McClelland S, Teng Q, Benson LS, Boulis NM. Motor neuron inhibition-based gene therapy for spasticity. Am J of PM&R, in press.

Yang J, Teng Q, Garrity-Moses M, Federici T, Najm I, Chabardes S, Moffitt M, Boulis NM. Gene therapy of epilepsy by adenovirus-mediated tetanus toxin light chain gene transfer. Mol Therapy manuscript in press.

Federici T, Liu JK, Teng Q, Garrity-Moses M, Yang J, Boulis NM. Neuronal specific binding properties of a peptide isolated via phage display biopanning. Neurosurgery in press.


Submitted for Publication in Peer-Reviewed Journals

Yang J, Qingshan T, Garrity-Moses ME, Federici T, McClelland S III, Boulis NM. Hemiparkinsonism induced through unilateral expression of adenovirus-mediated clostridial light chain gene in the substantia nigra. Neuromolecular Medicine, submitted.

Steinmetz MP, Krishnaney A, Boulis NM, Benzel EC. Clinical Problem Solving; An invasion of the Atlas. Neurosurgery submitted.

Lee JYK, Walter B, Deogaonkar M, Boulis NM, Starr P. Clinical Problem Solving; Find the target. Neurosurgery submitted.

Khatib R, Ebrahim Z, Rezai A, Boulis NM, Doyle DJ, Schurigyn T, Farag E. Perioperative events during deep brain stimulation; The experience at the Cleveland Clinic. Anesthesia and Analgesia, submitted.

Ugokwe K, Chahlavi A, Bingaman W, Gupta A, Prayson R, Boulis NM, Montes J. Clinical Problem Solving; Seize the Day. Neurosurgery submitted.

Spiotta AM, Bain MA, Deogaonkar M, Hammert W, Boulis NM, Rezai A. Scalp fasciocutaneous flap and cranioplasty for threatened scalp erosion of deep brain stimulator hardware. submitted, Neurosurgery.

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Manuscripts in Preparation

Toms S, Weil RJ, Prayson R, Boulis NM, Sawaya. Clinical Problem Solving, Island Intruder. In prep, Neurosurgery.



Non-Peer Review Book Chapters and Review Articles

Boulis NM, Armstrong W, Antman, E and Lilly, L. Mechanisms of Cardiac Arrhythmias. In Lilly, L. ed. Pathophysiology of Heart Disease. Malvern: Lea and Febiger, 1993

Boulis NM, Armstrong W, Antman, E and Lilly, L. Diagnosis of Cardiac Arrhythmias. In Lilly, L. ed. Pathophysiology of Heart Disease. Malvern: Lea and Febiger, 1993

Scott RM, Sathi S, Boulis NM. Tumors and Cysts of the Dysraphic Spine . In Menezes AH, and Sontag VKH ed. The Principles of Spinal Surgery. New York: McGraw-Hill, 1996

Armstrong WS, Boulis NM, McGillicuddy JE. Infections of the Central Nervous System. In Crockard A, Hayward R, Hoff JT ed. Neurosurgery the Scientific Basis of Clinical Practice IIIrd Edition. Boston: Blackwell Scientific, 2000; 757-783

Muraszko KM, Boulis NM, Turner DE. Tethered Cord Release. In Batjer HH and Loftus CM eds. Textbook of Neurological Surgery. Philadelphia: Lippincott-Raven Publishers, 2003.

McGillicuddy JE and Boulis NM. Techniques of Nerve Repair. in Neurosurgery, 3rd ed. (Wilkins and Rengenchary eds), accepted in 2002: Publishers canceled printing of the book in 2005.

Baker KB, Boulis NM, Montgomery EB, Rezai A. Target selection using microelectrode recordings. Microelectrode Recording in Movement Disorder Surgery. (Israel and Burchiel eds), Thieme, New York; pp138-151, 2004.

Rosenow JM, Boongird A, Boulis NM, Rezai A. Surgical procedure for STN Stimulation. In Brain Stimulation and Epilepsy (Luders H ed),Chap 26, 323-327.

Garrity-Moses M, Liu J, Boulis NM. Molecular Biology and Gene Therapy in the Treatment of Chronic Pain. In Neurosurgery Clinics of North America: Neuroaugmentation for Chronic Pain, (Henderson J ed) WB Saunders Co, Elsevier Pub.Vol 14(3): 419-435, 2003.

Kopell B and Boulis NM. Setting Up a Movement Disorder Surgery Practice. In Movement Disorder Surgery; The Essentials. (Bakay R ed) Thieme Pub in press.

Boulis NM, Rezai AR, Song DK. Thalamotomy. In Therapy of Parkinson's Disease. Third Edition 2004 (Lyons, Kollers and Pahwa ed), Chap 19; 247-266, 2004.

Steinmetz, MP, Liu, JK, Boulis, NM. Cellular and Gene Therapy Approaches to Spinal Cord Injury. In Molecular Neurosurgery. (Freese, Simeone, Janson and Leone eds) Karger Publishers, Prog Neurolo Surg, pp 65-103, 2005.

Borsellino SR, Lastra JJ, Boulis NM, Benzel EC. Surgical exposure of peripheral nerves of the upper extremity Part I-Median Nerve. In Neurosurgical Operative Atlas (Rengenchary SS, Wilkins RH eds) AANS Publication Committee, in press.

Borsellino SR, Lastra JJ, Boulis NM, Benzel EC. Surgical exposure of peripheral nerves of the upper extremity Part II- Radial Nerve. In Neurosurgical Operative Atlas (Rengenchary SS, Wilkins RH eds) AANS Publication Committee, in press.

Teng Q, Federici T, Boulis NM. Viral vector axonal uptake and retrograde transport: Mechanisms and Applications. In Gene Therapy and the Brain (Kaplitt M and During MJ eds) WB Saunders Co, Elsevier Pub, pp 253-267, 2005.

Alexopoulos AV, Gonugunta V, Yang J, and Boulis NM. Electrical stimulation and gene-based neuromodulation for control of medically-refractory epilepsy. In Operative Neuromodulation (Sakas, Simpson, Kranes eds), Acta Neurochir Suppl 97: 1-17, 2007.

Riley J and Boulis NM. Molecular and cellular mechanisms and treatment of pain. Clinical Neurosurgery Vol 53.

Tsao B, Boulis NM. Peripheral Nerve Trauma. Neurology in Clinical Practice, 5th Edition. (Bradley WG, Daroff RB, Fenichel GM, Jankovic J eds.) Elsevier Pub, in press.

Robert E, Riley J, and Boulis NM. Experimental Advances in Tumors of the Peripheral Nervous System. In Neurosurgery Focus (Kline D and Tiel R eds). AANS Pub, in press.

Federici T and Boulis NM. Protein, cell, and gene-based neuromodulation. In Textbook of Neuromodulation (Krames E, Peckham H, and Rezai eds). Blackwell Pub, in press.

Federici T and Boulis NM. The relevance of molecular targeting and therapeutics to neurosurgical practice (RNAi). Clinical Neurosurgery Vol 54.

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Abstracts

Kehne J, Boulis NM, and Davis M (1987) Rolipram-induced increase in sensorimotor reactivity measured with acoustic startle: sites of action and possible monoaminergic mechanisms. Neuroscience Abstracts 13: 997

Boulis NM, and Davis M (1987) Sensitization of acoustically and electrically elicited startle responses by footshock. Neuroscience Abstracts 13: 643

Mazer J, Boulis NM, and Sahley C (1987) Plasticity in the shortening reflex of the semi-intact leech; behavioral and cellular analysis. Neuroscience Abstracts 13: 615

Karrer T, Boulis NM, Ehrlich J, and Sahley C (1989) Serotonin depletion reduces behavioral facilitation in the leech Hirudo medicinalis. Neuroscience Abstracts 15: 1142

Boulis NM and Davis M (1989) Effects of intrathecally administered isoquinoline sulfonamides H-7, H-8, and HA-1004 on acoustic startle. Neuroscience Abstracts 15: 1009

Boulis NM and Benowitz LI (1993) A Partial Purification of the Regenerating Optic Nerve Glial (RONG) Factor. Cobb Assembly Abstract: Boston Society of Neurology and Psychiatry

Boulis NM, Winikoff J, Irwin NI, Gu M.-F, Chen D.-F, Zanjani H, and Benowitz LI (1993) Endogenous trophic factors involved in regeneration of the goldfish optic nerve. Neuroscience Abstracts 19: 55

Schwalb JM, Boulis NM, Gu M-F, Irwin N, and Benowitz LI (1994) Characterization of two endogenous trophic factors involved in regeneration of the goldfish optic nerve. Neuroscience Abstracts 20: 1325

Schwalb JM, Gu M-F, Stuermer CAO, Bastmeyer M, Yoon CH, Jachna BR, Boulis NM, Irwin N, Benowitz LI. (1995) Factors that induce axonal regeneration in goldfish retinal ganglion cells derive from defined glial populations and act independently of priming lesions. Neuroscience Abstracts 21: 309

Boulis NM, Bhatia V., Holman HT, Brindle TI, Krauss DJ, Hoff JT, Betz AL. (1997) Adenoviral Gene Expression in the Rat Spinal Cord. Neuroscience Abstracts 23:1404

Boulis NM, Bhatia V, Anlar B, Brindle TI, Feldman EL (1998) Retrograde adenoviral gene delivery to rat spinal cord via sciatic nerve microinjection. Neuroscience Abstracts 24: 1404

Boulis NM, Bobek MP, Schmaier A, Hoff JT. Rapid correction of warfarin coagulopathy in intracranial hemorrhage. (1998) Abstracts of the American Association of Neurological Surgeons: 370

Gong C, Keep RF, Boulis NM, Betz AL. Inducible cyclooxygenase-2 expression after intracerebral hemorrhage. (1999) Neuroscience Abstracts 25: 827

Boulis NM, Turner DE, Feldman EL, Imperiale MJ. Adenoviral gene expression in spinal cord following remote vector delivery. Abstracts of the American Society of Gene Therapy 2: 208

Boulis NM, Kim HM, Mian FS, Hoff JT. Urinary retention following routine neurosurgical spinal procedures. (2000) Abstracts of the American Association of Neurological Surgeons: 98

Boulis NM, Turner DE, Imperiale MJ. Creation of two adenoviral vectors for stereotactic insulin-like growth factor I gene therapy. (2000) Abstracts of the American Association of Neurological Surgeons: 116

Boulis NM, Noordmans AJ, Feldman EL, Imperiale MJ. (2000) Adeno-associated viral gene expression in the adult rat spinal cord following remote vector delivery. Molecular Therapy 1(5): S110-S111

Noordmans AJ, Hilgendorf A, Boulis NM, Imperiale MJ. (2000) Prolonged gene expression following direct spinal cord injection of AdLAPAP in the adult rat. Molecular Therapy 1(5): S111

Boulis NM, Gong C, Jun G, Turner DE, Hoff JT, Keep RF. DNA fragmentation and Caspace-3 activation following intracerebral hemorrhage. (2000) Congress of Neurological Surgeons

Boulis NM, Muraszko KM. Project Shunt: A model for collaborative efforts in the developing world. (2001) Abstracts of the American Association of Neurological Surgeons: 148

Boulis NM, Noordmans AJ, Feldman EL, Imperiale MJ. Adeno-associated viral vectors enhance central nervous system gene delivery with remote injection. (2001) Abstracts of the American Association of Neurological Surgeons: 198

Rubin AD, Hogikyan N, Boulis NM, Sullivan K, Feldman EL. Remote delivery of rAAV-GFP to the rat brainstem via the recurrent laryngeal nerve. (2001) Neuroscience Abstracts: 871.3.

Noordmans AJ, Song DK,. Noordmans CJ, Boulis NM. Adeno-associated viral gene expression in the lateral nucleus of the rat hypothalamus. (2001) Neuroscience Abstracts: 246.8.

Song DK, Boulis NM, Noordmans AJ, Erikson NA, Russell JR*, Feldman EL. Remote adeno-associated viral gene delivery to the spinal cord and dorsal root ganglion in streptozotocin-treated mice. (2001) Neuroscience Abstracts: 361.5.

Boulis NM, Russell JW, Song DK, Noordmans AJ, Feldman EL. Toward a biological surgery for diabetic neuropathy. Abstracts of the Congress of Neurological Surgeons (2001)

Boulis NM, Noordmans AJ, Song DK, Feldman EL. Stereotactic gene based hypothalamic neuromodulation. Abstracts of the American Association of Neurological Surgeons (2002)

Vincent AM, Boulis NM, Jung V, Song DK, Imperiale MJ, Feldman EL. AAVCMV.IGF-I.IRES.GFP based neuroprotection in an in vitro model of Amyotrophic Lateral Sclerosis. Molecular Therapy 5(5):S96. (2002).

Boulis NM, Erikson N, Song DK, Imperiale MJ. Intraneural colchicine inhibits remote spinal cord delivery of adenovirus and AAV. Molecular Therapy 5(5):S300, (2002).

Watson P, Montgomery EB, Baker KB, Rezai A, Boulis NM, Henderson J. Subthalamic nucleus (STN) neuronal activity in meaningful and non-meaningful speech. Abstracts of The Movement Disorder Society, in press.

Schuele SU, Kellinghaus C, Bethoux FA, Boulis NM, Loddenkemper T. Frequency of seizures in Multiple Sclerosis Patients treated with intrathecal baclofen. Abstracts of the American Epilepsy Society, in press.

Rosenow J, Boulis N, Analysis of Infections in Implanted Deep Brain Stimulation hardware. (2003) Abstracts of the American Association of Neurological Surgeons

Qinshan T, Garrity-Moses M, Boulis NM. Adeno-associated virus-mediated gene transfer of BclX L for motor neuron protection. (2003) CWRU Research ShowCASE.

Garrity-Moses ME, Qingshan T, Tanase D, Liu J, Bhat M, Boulis NM. (2003) AAVCMV.Bcl-xLGFP gene delivery to SHSY5Y neuroblastoma cells as a neuroprotective agent in glutamate-induced apoptosis. Molecular Therapy 7(5): S96.

Tanase D, Garrity-Moses ME, Liu JK, Teng Q, Mazarakis N*, Boulis NM. (2003) Techniques for Remote Cervical Spinal Cord Delivery of Neurotherapeutic RabG-EIAV Encoded Genes. Molecular Therapy 7(5): S97.

Liu JK, Qingshan T, Garrity-Moses ME, Tanase D, Imperiale MJ, Boulis NM. Strategy for the development of neurotropic AAV: biopanning for neurotropic peptides. Molecular Therapy 2003 7(5): S351.

Teng Q, Liu JK, Tanase D, Garrity-Moses ME, Boulis NM. (2003) Gene Based Model for the Development of Countermeasures to Clostridial Bioterrorism. Molecular Therapy 7(5): S97.

Garrity-Moses ME, Teng Q, Tanase D, Liu J, Rezai A, Boulis NM. (2003) AAV.CMV.Bcl-xL-GFP Motor Neuron Protection Against Excitotoxicity In Vitro. Neuroscience Abstracts 789.1.

Liu J, Teng Q, Tanase D, Garrity Moses ME, Baker K*, Boulis NM. (2003) Short Peptides with Clostridial Ganglioside Binding Properties Defined through Phage Display. Neuroscience Abstracts 495.6.

Teng Q, Liu JK, Tanase D, Garrity-Moses ME, Boulis NM. (2003) Synaptobrevin digestion in vitro with a tetanus light chain adenoviral vector. Neuroscience Abstracts 54.5.

Tanase D, Garrity-Moses ME, Liu JK, Teng Q, Boulis NM. (2003) In vivo synaptic inhibition through intracellular tetanus light chain expression. Neuroscience Abstracts 900.5.

Garrity-Moses ME, Boninsegna S, Teng Q, DalToso R, Boulis NM, Albensi BC * and Janigro D. (2003) Biosil encapsulation of mammalian cells: a novel strategy for cell-mediated drug delivery. Neuroscience Abstracts 789.1.

Cooper SE, Baker K, Boulis NM, Henderson J, Rezai A, Montgomery EB, Grill WM. (2003) Paired pulse deep brain stimulation of thalamus in essential tremor: tremor suppression and paresthesias. Neuroscience Abstracts 97.20.

Boulis NM, Teng Q, Liu J, Tanase D, Garrity-Moses M. Neurosurgical Gene-based Alternative to Deep Brain Stimulation and Botulinum Toxin. (2004) Abstracts of the American Association of Neurological Surgeons.

Liu J, Teng Q, Tanase D, Garrity Moses ME, Boulis NM. Neuronal membrane specific binding peptides isolated via phage display biopanning against trisialogangliosides.. Mol Therapy 9(Supp1): S167.

Tanase D, Garrity-Moses ME, Liu JK, Teng Q, Mazarakis N, Walmsely L, Azzouz M, Boulis NM. Cervical spinal cord delivery of a lentiviral vector in SOD-1 transgenic mice. Mol Therapy 9(Supp1): S201.

Teng Q, Garrity-Moses M, Liu J, Tanase D, Mazarakis N, Azzouz M, Walmsely L, Boulis NM. EIAV-IGF-I Gene Transfer to Motor Neurons Enhances Axonal Length in Vitro. Mol Therapy 9(Supp1): S280.

Krishnaney A, Zhao Z, Teng Q, Liu J, Garrity-Moses M, Davis M, Boulis NM. Adenoviral Light Chain Gene Expression in the Brainstem Induces Specific Motor Inhibition. Mol Therapy 9(Supp1): S19.

Pilitsis, JG, Rezai A, Boulis NM, Henderson JM, Busch RM, Kubu CS. Postoperative confusion following STN DBS predicts greater neuropsychological difficulties in the longterm: Preliminary Findings. (2005) American Association of Neurological Surgeons

Liu, JK, Tanase, D, Garrity-Moses, M, Teng, Q, Boulis NM Neuronal Binding of a Novel 12 AA Peptide Defined by Phase Display. Society for Neuroscience Abstract 876.9.

Tanase D, Teng Q, Liu JK, Garrity-Moses ME, Boulis NM Reversible Neuromuscular Inhibition Through Transient Spinal Cord Tetanus Light Chain Gene Expression. Society for Neuroscience Abstract 874.6

Garrity-Moses ME, Teng Q, Liu JK, Tanase D, Rezai A, Boulis NM. Adenoviral XIAP Expression Protects Motor Neurons In An In Vitro Model of Amyotrophic Lateral Sclerosis. Society for Neuroscience Abstract 312.10

Boulis NM, Garrity-Moses ME, Liu JK, Tanase D, Tang Q. EIAV-IGF-I Gene Transfer to Motor Neurons Enhances Motor Neuron Survival and Axonal Length. Society for Neuroscience Abstract 134.5

Teng Q, Liu JK, Tanase D, Garrity-Moses ME, Boulis NM. AAVTET-ONLC: A Means For Controlled Synaptic Inhibition. Society for Neuroscience Abstract 12.4

Boulis NM, Yang, J, Teng Q, Garrity-Moses M, Tanase D. RabG.EIAV-IGF-I peripheral injection prolongs survival in a mouse ALS model through retrograde gene delivery. (2005) Abstracts of the American Association of Neurological Surgeons.

Boulis NM, Garrity-Moses M., Qingshan T. Development of anti-apoptotic gene transfer as a means for neuroprotection against excitotoxicity. (2005) Abstracts of the American Association of Neurological Surgeons.

Yang J, Teng Q, Garrity-Moses M, Federici T, Najm I, Chabardes S, Moffitt M, Boulis NM Gene therapy of epilepsy by adenovirus-mediated tetanus toxin light chain gene transfer. Molecular Therapy 11: (Suppl. 1) S168 #433, 2005.

Garrity-Moses M, Teng Q, Yang J, Federici T, Gilbert E, SubramanianT, Boulis NM Adenoviral clostridial light chain expression in the medial forebrain bundle: a reversible model of dopamine depletion. Molecular Therapy 11: (Suppl. 1) S405 #1050, 2005.

Teng Q, Federici T, Garrity-Moses M, Yang J, Reiser J, Boulis NM Neuronal gene transfer with HIV-1-based lentiviral vectors pseudotyped with lyssavirus glycoproteins. Molecular Therapy 11: (Suppl. 1) S187 # 482, 2005.

Federici T, Liu JK, Teng Q, Garrity-Moses M, Yang J, Boulis NM. In vivo spinal cord uptake and neuronal binding properties of Tet1: a potential means for enhanced spinal cord AAV delivery. Molecular Therapy 11: (Suppl. 1) S332 #855, 2005.

Davis A, Stachler M, Shi W, Liu JK, Boulis NM, Bartlett JS. Manipulating AAV2 tropism for enhanced delivery of AAV vectors to the spinal cord. Molecular Therapy 11 (Suppl. 1) S46, #113, 2005.

Liu JK, Federici T, Boulis NM. (2005) Novel Neuronal Membrane Targeted 12 Amino Acid Peptides Defined Through Phage Display. 9th International Conference on Neural Transplantation and Repair.

Boulis NM, Yang J, Teng Q, Najm I, Chabardes S, Moffit, Garrity-Moses M. Light Chain Gene-based Control of neocortical epilepsy. Abstracts of the Congress of Neurological Surgeons, 2005.

Liu JK, Federici T, Teng Q, Garrity-Moses M, Yang J, Tanase D, Boulis NM. In vivo neuronal bindig properties of Tet1: a peptide isolated from a random 12mer phage display library. Society for Neuroscience Abstract 229.17, 2005.

Federici T, Liu JK, Teng Q, Garrity-Moses M, Yang J, Boulis NM. Phage display identification of C7C loop peptide with neuronal affinity. Society for Neuroscience Abstract 229.10, 2005.

H. Kuroda, Teng Q, Garrity-Moses M, Federici T, Yang J, Kutner R, Tordo N, Carlton E, Krudy C, Reiser J, Boulis NM. Pseudotyping HIV-1 based lentiviral vectors with lyssavirus glycoproteins for neuronal gene transfer. Society for Neuroscience Abstract 228.15, 2005.

Yang J, Teng Q, Garrity-Moses MG, Federici T, Najm I, Chabardes S, Moffitt M, Alexopoulos A, Riley J, Boulis NM. Cortical clostridial light chain gene-based synaptic inhibition inhibits neocortical seizures. Society for Neuroscience Abstract 244.11, 2005.

Garrity-Moses MG, Teng Q, Gilbert E, Yang J, Federici T, Boulis NM. Synaptobrevin digestion results in dopamine depletion in the medial forebrain bundle. Society for Neuroscience Abstract 494.7, 2005.

Hayek S, Henderson J, Boulis N, Kapural L, Stanton-Hicks M, Nagy M. Peripheral nerve stimulation for post surgical facial neuralgias. Program and abstracts of the 21st Annual Meeting of the American Academy of Pain Medicine; February 23-27, 2005; Palm Springs, California. Abstract 105.

Teng Q, Bartlett JS, Federici T, Yang J, Boulis NM. Tetanus toxin heavy chain-streptavidin fusion protein targeted motor neuron gene delivery through metabolically biotynilated AAV. Molecular Therapy 13(S1), S193, 2006.

Yang J, Qingshan T, Federici T, McClelland S III, Boulis NM. Hemiparkisonism induced through unilateral expression of Adenovirus-mediated clostridial light chain gene in the Substantia Nigra. Molecular Therapy 13(S1), S92, 2006.

Boulis NM, Federici T, Garrity-Moses M, Krudy C, Teng Q, Yang J. Adenovirus-light chain inhibition of growth hormone release from pituitary adenoma cells. Molecular Therapy 13(S1), S54, 2006.

Federici T, Liu JK, Teng Q, Garrity-Moses M, Yang J, Boulis NM. Neuronal affinity of a C7C Loop peptide identified through phage display. Molecular Therapy 13 (S1), S195, 2006.

Ford PJ, Deshpande A, Boulis NM, Murphy C, Benzel EC. Teaching Ethics: A review of resident's ethics cases. Select Abstract; Congress of Neurological Surgeons 2006.

Qingshan T, Federici T, Yang J, Bartlett J, Boulis NM. Targeted motor neuron and dorsal root ganglion gene delivery through tetanus toxin heavy chain-Streptavidin fusion protein and metabolically biotinylated AAV. Congress of Neurological Surgeons 2006.

Qingshan T, Federici T, Yang J, Boulis NM. Tetanus toxin heavy chain-Bcl-xL fusion proteins for targeted gene therapy of motor neuron diseases. Society for Neuroscience Abst. 708.5, 2006.

Yang J, Garrity-Moses M, Federici T, Qingshan T, Boulis NM. Clostridial light chain expression in the substantia nigra induces a reversible hemiparkinsonism in the rat. Society for Neuroscience Abst. 675, 2006.

McClelland S III, Bethoux FA, Sutliff MH, Stough DK, Schwetz KM, Gogol DM, Harrison M, Pioro EP, Boulis NM. (2006) Intrathecal baclofen for spasticity-related pain in Amyotrophic Lateral Sclerosis: Efficacy and facts associated with pain relief. Abstracts of the American Association of Neurological Surgeons.